From then on, everything went downhill for Izzie, and her appearances in the show became sporadic. Izzie left Seattle to start a new life and later sent divorce papers to Alex Karev. Adrienne Tyler is a features writer for Screen Rant. She is an Audiovisual Communication graduate who wanted to be a filmmaker, but life had other plans and it turned out great.
Adrienne is very into films and she enjoys a bit of everything: from superhero films to heartbreaking dramas, to low-budget horror films. But Izzie had my kids, and I know you get what that really means. We have loved writing Alex. For 16 seasons, 16 years, we have grown up alongside Alex Karev. We have been frustrated by his limitations and we have been inspired by his growth and we have come to love him deeply and to think of him as one of our very best friends.
We will miss him terribly. And we will always be grateful for his impact, on our show, on our hearts, on our fans, on the world. You can watch it above. Because the exit was so sudden, it took the writers time to craft a proper farewell for the character. Alex quickly become a fan favorite with his attentive skills in pediatrics and compassionate nature with friends. Initially disliked by his fellow interns because of his brusque and dismissive manner with patients and co-workers, he earned their respect because of his profound skill for his specialty.
Izzie and George O'Malley went to dermatology, Daisy Pepman removed her mole and told her she shouldn't be worried about it. Daisy later came back with her results that the mole was malignant.. Izzie gathers her interns and creates "Patient X" who is actually Izzie, had her interns try to diagnose her. The interns conclude that "Patient X" is fine, and at most she has an anxiety disorder. This makes Izzie very frustrated, saying "Patient X" has been having visual, auditory, and tactile hallucinations.
Izzie is conversing with George when Lexie Grey comes up to her, explaining they have new on "Patient X". Lexie explained they should check for a malignancy in the brain. Which was done by using an MRI. Izzie had multiple scans including an upper G. Izzie later asked what Lexie would say to "Patient X" if she had the chance. Izzie chose to tell Cristina about her cancer, and Cristina set her up with the best surgical oncologist in the state as well as producing masses of research, but Izzie chose to blow off the appointment, making Cristina wonder why she ever confided in her to begin with.
Eventually, Cristina couldn't handle the pressure and told an OR full of staff, including Alex and Bailey, of Izzie's diagnosis, which gave Izzie the final push to fight for her life, and she finally admitted herself into Seattle Grace as a patient. Izzie's first part of her treatment was to have the temporal lobe metastases removed by Derek, who returned to surgery to operate on Izzie following his breakdown.
Meredith also suggested to Izzie that she has obstetrics remove healthy eggs from her, for her future. The first stage of her treatment was successful, as Derek removed the tumor fully from Izzie's temporal lobe, no thanks to Rebecca Swender , Izzie's oncologist who constantly second-guessed Derek during surgery until Derek found his rhythm and quiets Dr.
Following the news of her cancer and Meredith and Derek's wedding, she began to plan the wedding and even created Meredith and Derek's Wedding Website.
However, after discovering another tumor in her brain due to the appearance of Denny, Meredith and Derek gave away their wedding to Izzie and Alex and they got married. She then did the risky surgery, and the tumor was successfully removed.
While Alex embraced Izzie after realizing that some of her memory returned, Izzie went limp and her pressure started dropping. Alex called for Cristina, who arrived shortly before Richard Webber and Miranda Bailey arrived and he demanded that they resuscitate her, but Cristina told the others that Izzie signed a DNR.
During the budget cuts at Seattle Grace, Izzie accidentally administered an incorrect dosage of medicine to a patient, causing her not to get a much-needed kidney transplant. This caused Chief Webber to fire her. Thinking Alex was partly to blame, Izzie wrote him a letter and left. Izzie later returned to Seattle for a final PET scan and to ask Derek to put in a good word for her, so she could get a job in Tacoma and repair things with Alex.
Derek learned that Tacoma didn't want to hire her because of her history, but he planned on hiring Izzie back once he was given the job of Chief of Surgery. At the same time, Izzie went to show Alex that her scan was clean, meaning she was officially not dying of cancer. He was genuinely happy for her but felt he deserved better. Knowing she was okay, he told her to leave, be happy, and not come back.
Realizing that there was nothing left to repair, Izzie went to Meredith's house to pack her stuff. Meredith begged her not to throw the people that loved her aside and not to leave, as it was her home.
Izzie responded saying that Seattle Grace wasn't her home anymore, that it was just a place she used to work at and she can do that anywhere. This makes a tearful Meredith frown and turn away, letting her go. As Izzie exhales, she is left to start all over again somewhere else. Around four years after leaving Seattle, Izzie was single and wanted children. Due to chemo for the cancer, she lost the ability to get pregnant, and she used the frozen embryos from before treatment to try and have kids.
It was successful and she gave birth to twins, whom she named Eli and Alexis. The three of them live out on the country in Baldwin City, Kansas, where she now works as a surgical oncologist. Five years after having twins, Meredith's medical license was in jeopardy. Alex called her to see if she could write a letter of support in the trial. Alex admitted the trial gave him an excuse to call her and see how she was doing many years later. As Alex and Izzie talked, he described it being as if no time had passed between them and felt they left something unfinished.
He later learned she had kids, and that in fact the kids were his. He then got on with the trial and went to see her and the kids. He eventually decided to stay with Izzie and their twins to build a life together. Izzie always thinks there's some good in people, no matter how bad they are. Her motivations are always for what she believes to be the right thing. She is very optimistic, bubbly, and bright. The first impression she gives is a confident and friendly woman.
She is also very kind, protective, and often stubborn. She seems to get too emotionally involved in most cases, which she sees as a good thing, although others feel it gets in the way of the medicine.
Izzie is very loyal to all her friends, and in most cases, can be trusted. She likes seeing others happy and is constantly trying to cheer people up. This attitude, however, is not extended to certain individuals. For example, she goes out of her way every chance she gets to belittle and bring down George and Callie after they eloped, eventually breaking the marriage up completely by sleeping with George. She is also a hopeless romantic.
Izzie can often be taken as a meddler when she tries to help people when they do not necessarily ask for help. She can really bring the pain if she believes she has been wronged or hurt emotionally. She can hold a grudge or retaliate when someone tries to take advantage of her kindness and good intentions.
When she started her internship, Izzie was dating the professional hockey player Hank. They soon broke up due to her long working hours and distance. When Alex Karev discovered her history as a model, he didn't waste any time in putting up her lingerie advertisements all over Seattle Grace Hospital. Despite the incident, she saw through Alex's shallow, callous exterior and befriended him, to the shock of her friends. When he eventually asked her out, she was disappointed that he didn't have the courage to kiss her.
For a while she refused to speak to him until spontaneously at Joe's bar, he kissed her. Despite dating Alex, a heart patient named Denny Duquette continually flirted with her.
It led nowhere and he left the hospital shortly after they met after failing to receive a new heart. Due to some difficulties on Alex's part, their sexual relationship didn't take off. And after Izzie caught Alex sleeping with Nurse Olivia , she ended their relationship and was furious with him.
When Izzie discovered her friends were helping Alex study for his failed boards she blew up at them although she eventually forgave him and helped him study as well. Even though she forgave him she ruled out the possibility of another relationship with him.
When there was a bomb scare in the hospital, Izzie felt she needed to do what she wanted before it was too late. She proceeded to have sex with Alex in a linen closet again several times throughout the day. Alex assumed that they were dating again but Meredith told him that they were only sleeping together and Izzie wouldn't ever think of him the same after his incident with Olivia.
Later, Izzie gave Alex an ultimatum. She told him either to be the nice guy or the jerk but he couldn't be both. He kissed her and they later decided to go steady. Things went well but Denny began to appear to Izzie and she even had sex with him.
Shockingly, it turned out that the appearances of Denny were because of an illness she had. Meredith and Derek gave their wedding to Izzie after discovering her tumor and she got married to Alex. Izzie's time with cancer was rough, and it took a toll on her relationship with Alex.
Eventually, she did come back, wanting to reunite with Alex when she found out her cancer was gone. However, he refused, wanting someone who would stay. Soon afterwards, she sent him divorce papers and he signed them. When Meredith needed letters for her trial, Alex called Izzie, and in their conversation she revealed that she had given birth to twins, using a frozen embryo that she and Alex had saved when she was starting her cancer treatment.
He went to Kansas to visit them, decided to stay, and began a life with Izzie and their family. When Denny was readmitted to the hospital after suffering cardiac dysrhythmia, Izzie brushed Alex off so she could tend to Denny.
Alex felt threatened by Denny so he told Denny he should back off because he would probably die from heart failure and if he did it would hurt Izzie.
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